Revised primary molecular cytogenetic classification of myeloma

FISH abnormality	Percentage of myeloma patients
Trisomy(ies) without IgH abnormality	42
IgH abnormality without trisomy(ies)	30
t(11;14)	15
t(4;14)	6
t(14;16)	4
t(14;20)	<1
Unknown partner/deletion of IgH region	5
IgH abnormality with trisomy(ies)	15
t(11;14)	3
t(4;14)	4
t(14;16)	1
t(6;14)	<1
Unknown partner/deletion of IgH region	7
Monosomy 14 in absence of IgH translocations or trisomy(ies)	4.5
Other cytogenetic abnormalities in absence of IgH translocations or trisomy(ies) or monosomy 14*	5.5
Normal	3

The table describes the distribution of various abnormalities detected by fluorescent in situ hybridization (FISH) in a population of 484 patients with newly diagnosed symptomatic multiple myeloma.

* These included primarily monosomy 13 and p53 abnormalities.

This research was originally published in Blood. Kumar S, Fonseca R, Ketterling RP, et al. Trisomies in multiple myeloma: impact on survival in patients with high-risk cytogenetics. Blood 2012; 119:2100. Copyright © 2012 American Society of Hematology.

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Revised primary molecular cytogenetic classification of myeloma