Version May 2024
| Clinical | Histologic |
| Dryness (roughness) | Increased compaction of stratum corneum, increased thickness of granular cell layer, reduced epidermal thickness, reduced epidermal mucin content |
| Actinic keratoses | Nuclear atypia, loss of orderly, progressive keratinocyte maturation; irregular epidermal hyperplasia and/or hypoplasia; occasional dermal inflammation |
| Irregular pigmentation | |
| Freckling | Reduced or increased number of hypertrophic, strongly DOPA-positive melanocytes |
| Lentigines | Elongation of epidermal rete ridges; increases in number and melanization of melanocytes |
| Guttate hypomelanosis | Reduced number of atypical melanocytes |
| Diffuse irreversible hyperpigmentation (bronzing) | Increased number of DOPA-positive melanocytes and increased melanin content per unit area and increased number of dermal melanophages |
| Wrinkling | |
| Fine surface lines | None detected |
| Deep furrows | Contraction of septae in the subcutaneous fat |
| Stellate pseudoscars | Absence of epidermal pigmentation, altered fragmented dermal collagen |
| Elastosis (fine nodularity and/or coarseness) | Nodular aggregations of fibrous to amorphous material in the papillary dermis |
| Inelasticity | Elastotic dermis |
| Telangiectasia | Ectatic vessels often with atrophic walls |
| Venous lakes | Ectatic vessels often with atrophic walls |
| Purpura (easy bruising) | Extravasated erythrocytes and increased perivascular inflammation |
| Comedones (maladie de Favre et Racouchot) | Ectasia of the pilosebaceous follicular orifice |
| Sebaceous hyperplasia | Concentric hyperplasia of sebaceous glands |
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