Radiation biodosimetry

Dose (Gy)	Vomiting (percent)	Time to vomiting (hours)	ALC day 1*	Lymphocyte fall rate constant (k)^¶	Lymphocyte dicentrics (per 1000)^Δ
0	0	-	2450	-	1-2
1	19	-	2160	0.126	88
2	35	4.6	1900	0.252	234
3	54	2.6	1680	0.378	439
4	72	1.7	1480	0.504	703
5	86	1.3	1310	0.63	1000
6	94	1	1150	0.756
7	98	0.8	1010	0.881
8	99	0.7	890	1.01
9	100	0.6	790	1.13
10	100	0.5	700	1.26

Gy: absorbed whole body dose in Gray units.
* ALC day 1: absolute lymphocyte count per microL on day 1 after exposure.
¶ The lymphocyte fall rate constant is derived from a semilogarithmic plot of the absolute lymphocyte count (ALC) versus time in days, in the form of 2450 x e^–kt. The time (in days) for the ALC to fall to one-half of its original value [half-time, T(1/2)] can be obtained from the following equation: T(1/2) = 0.693/k.
Δ Dicentric chromosomes are those containing two separate centromeres, caused by end-to-end recombination of two damaged chromosomes.

Modified with permission from: Waselenko JK, MacVittie TJ, Blakely WF, et al. Medical management of the acute radiation syndrome: Recommendations of the strategic national stockpile radiation working group. Ann Intern Med 2004; 140:1037. Copyright © 2004 American College of Physicians.

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Radiation biodosimetry