Syndromes that have obstructive sleep apnea as a finding and the factors that contribute to the obstruction

Syndrome	Micro- gnathia	Maxillary Hypoplasia (Small Nasal Capsule)	Choanal Atresia or Stenosis	Cranial Base Anomalies	Hypotonia of Pharynx	Macro-glossia	Other Anomalies
Achondroplasia		+	+	+
Apert		+	+	+
Beckwith-Wiedemann					+	+	CNS anomalies
Camptomelic and dysplasia	+						Tracheal, bronchial cartilage anomalies;
Cerebro- costo- mandibular	+
Charge association			+		+		CNS anomalies
Crouzon		+	+	+			Tracheal ring anomalies
De Lange	+				+		CNS anomalies
Diastrophic dysplasia	+			+
Femoral dysgenesis	+
Fetal alcohol	+				+		CNS anomalies
Fetal hydantoin	+						CNS anomalies
Freeman-Sheldon	+						Multiple contractures
Fronto- metaphyseal dysplasia	+			+			Cranial overgrowth; scoliosis
Hallermann-Streiff	+	+
Hemifacial microsomia	+				+		Pharyngeal asymmetry
Holo- prosencephaly sequence		+	+	+	+		CNS anomalies
Larsen's	+						Connective tissue dysplasia
Marshall- Smith	+	+	+	+	+		CNS anomalies
Nager	+	+	+	+
Otopalato- digital	+			+
Pfeiffer		+	+	+			Tracheal ring anomalies
Prader-Willi					+		CNS anomalies
Pykno- dysostosis	+	+		+
Robin sequence (isolated)	+
Rubinstein-Taybi	+	+		+	+		CNS anomalies
Shprintzen			+		+		Laryngeal web; retrognathia
Shprintzen-Goldberg	+	+		+	+
Spondylo- epiphyseal dysplasia	+
Stickler	+	+		+			Short genioglossus; soft tracheal cartilage
Storage disorders (lysosomal, etc)				+
Steinert	+				+		Myotonia
Townes	+			+
Treacher Collins	+	+	+	+
Turner	+						Short neck
Chromosome disorders
Down syndrome (Trisomy 21)		+		+	+	+	CNS anomalies
Trisomy 18	+			+	+		CNS anomalies
Trisomy 13	+			+	+		CNS anomalies; holoprosencephaly
Trisomy 4p	+					+	CNS anomalies; short neck
6q-deletion	+						CNS anomalies; laryngeal dysfunction

Graphic 82466 Version 3.0