Differences between naïve and memory T cells

	Naïve	Effector	Memory
Surface phenotype	CD45RA	CD45RA/RO	CD45RO
	CD44 lo	CD44 hi	CD44 hi
	Integrins lo	Integrins hi	Integrins hi
	CD29 lo	CD29 hi	CD29 hi
	CD25 lo	CD25 hi	CD25 lo
Response to stimulation
Antigen/APC	Low		High
Cytokine production	Mainly IL-2		Th1/Th2
Low concentration anti-CD3 Ab	No		Yes
Anti-CD2 Ab	Low		High
Need for costimulation	High		Low

CD: cluster of differentiation; CD45RA: marker of naïve (nonactivated) T cells; CD45RO: marker of memory (activated) T cells; lo: low expression; hi: high expression; APC: antigen-presenting cell; IL-2: interleukin 2; Th1/Th2: T helper cell type 1/T helper cell type 2; Ab: antibody.

Graphic 82133 Version 4.0

آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟