Version June 2024
| Systemic allergic reactions |
| Anaphylaxis |
| Serum sickness |
| Cutaneous reactions |
| Rash |
| Stevens-Johnson syndrome |
| Erythema muliforme |
| Urticaria |
| Toxic epidermal necrolysis |
| Photodermatis |
| Gastrointestinal and hepatic reactions |
| Nausea and vomiting |
| Diarrhea |
| Hepatotoxicity |
| Hematologic reactions |
| Pancytopenia |
| Agranulocytosis |
| Anemia |
| Thrombocytopenia |
| Renal disorders |
| Transient rise in creatinine due to impaired secretion by trimethoprim |
| Acute interstitial nephritis |
| Crystalluria due to precipitation of sulfamethoxazole |
| Hyperkalemia due to trimethoprim-induced blockade of collecting tubule sodium channel |
| Other reactions |
| Central nervous system - headache, confusion, aseptic meningitis |
| Fever |
| Phlebitis |
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