Normal response to metyrapone

Serum concentrations of 11-DOC and cortisol before and after the administration of metyrapone (750 mg every four hours for six doses) in normal subjects. The fall in serum cortisol concentrations stimulates the secretion of ACTH, leading to a marked increase in serum 11-DOC concentrations. To convert serum deoxycortisol values to nmol/L, multiply by 28.9.