Hormone therapy in the treatment of desmoid tumors

Agents used	Number of patients	Duration of therapy (in months)	Response	Duration of response	Author; year
Toremifene or tamoxifen followed by toremifene*	20	1 to 29 (median 5.5)	65% CBRR	NR	Brooks M; 1992
Testolactone	10	2 to 60 (median 6.5)	2 CR^¶ 2 PR 6 PD	NR	Waddell W; 1991
Progesterone	11	NR	6 CR 2 PR 3 SD/PD^Δ	NR	Lanari A; 1983
Raloxifene	13	12 to 29	8 CR 5 PR	NR	Tonelli F; 2003
Toremifene	27	NR	7 PR 19 SD 2 PD	NR	Fiore M; 2011

CBRR: chemical benefit response rate; NR: not reported; CR: complete response; PR: partial response; PD: progressive disease; SD: stable disease.
* One patient was treated with toremifene for a month, was discontinued due to blurry vision, and was started on tamoxifen.
¶ In some cases, response evaluation was accomplished by palpation.
Δ Author describes outcome as "did not improve with progesterone" and does not specify patients who had SD and PD.

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Hormone therapy in the treatment of desmoid tumors