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Recommendations for preoperative and postoperative anticoagulation in patients on a vitamin K antagonist

Recommendations for preoperative and postoperative anticoagulation in patients on a vitamin K antagonist
Indication Before surgery After surgery
Venous thromboembolism
Within first month IV heparin or SQ LMWH IV heparin or SQ LMWH
Second/third month No change* IV heparin or SQ LMWH
≥3 months No change* SQ heparin or LWMH
Arterial thromboembolism
Recent, within one month IV heparin or SQ LMWH IV heparin or SQ LMWH
Prophylaxis (eg, non-valvular AF, mechanical heart valve) No change* Resume oral anticoagulation
NOTE: Warfarin should be withheld to allow the INR to fall spontaneously to 1.5 to 2 before surgery is performed.
IV: intravenous; SQ: subcutaneous; LMWH: low molecular weight heparin; AF: atrial fibrillation; INR: international normalized ratio.
* If the patient is hospitalized, SQ heparin or LMWH should be administered, but hospitalization is not recommended solely for this purpose.
¶ Can use SQ heparin or SQ LMWH if the surgery carries a high risk of postoperative thromboembolism.
Graphic 81389 Version 4.0

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