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Chance of side effects with certain antidepressant medicines

Chance of side effects with certain antidepressant medicines
Generic name US brand name Dry mouth,
blurred vision,
trouble urinating,
constipation,
dizziness
Drowsiness Trouble sleeping,
jitteriness
Nausea,
vomiting,
diarrhea
Weight gain Sexual problems
Selective serotonin reuptake inhibitors ("SSRIs")*
Citalopram Celexa None None Very low Very low Very low Moderate
Escitalopram Lexapro None None Very low Very low Very low Moderate
Fluoxetine Prozac, Sarafem None None Low Very low Very low Moderate
Fluvoxamine Luvox (only sold as generic in US) None Very low Very low Very low Very low Moderate
Paroxetine Paxil, Pexeva, others Very low Very low Very low Very low Low High
Sertraline Zoloft None None Low Low Very low Moderate
Atypical agents
Bupropion Wellbutrin, Aplenzin, others None None

Quick-release: Low

Sustained-release: Very low
Very low None None
Mirtazapine Remeron Very low High None None High Very low
Serotonin-norepinephrine reuptake inhibitors ("SNRIs")*
Desvenlafaxine Pristiq, Khedezla None Very low Low Very low (after week 1) None Moderate
Duloxetine Cymbalta None None Low Low None Moderate
Levomilnacipran Fetzima Very low None Very low Low None Low
Milnacipran Savella None Very low None Low None Low
Venlafaxine Effexor None Very low Low

Quick-release: Low

Extended-release: Very low
None Moderate
Serotonin modulators
Trazodone Desyrel (only sold as generic in US) None High None

Sleep-aid dose: Very low

Antidepressant dose: Moderate

Sleep-aid dose: None

Antidepressant dose: Very low
Very lowΔ
Vilazodone Viibryd None None Low High None Low
Vortioxetine Trintellix None None Very low Very low Very low Low

* All SSRIs and SNRIs can cause nausea and upset stomach at first or when increasing the dose. This usually goes away after about a week. Also, some SNRIs such as venlafaxine can increase your blood pressure. Talk to your doctor if you have high blood pressure.

¶ Sertraline is more likely than other SSRIs to cause diarrhea.

Δ Trazodone can cause an erection that lasts too long. This is a medical emergency.
Created with data from:
  1. Lexicomp Online. Copyright © 1978-2024 Lexicomp, Inc. All Rights Reserved.
  2. Serretti A, Chiesa A. Sexual side effects of pharmacological treatment of psychiatric disease. Clin Pharm Ther 2011; 89:142-7.
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