Immunophenotypic and pathologic features of triple negative breast cancer

Immunophenotypic characteristics

Estrogen and progesterone receptor-negative

HER2 negative

P-63 negative

P-cadherin negative

KIT-positive

Cytokeratin (CK) 5/6 positive

HER1 (EGFR) positive

Vimentin positive

Pathologic characteristics

BRCA1 germline mutations

p53 mutations (approximately 80 percent)

Ductal and metaplastic histology

Geographic necrosis

High-grade (grade 3)

High proliferative rate

Nuclear pleomorphism

Pushing borders of invasion

EGFR: epidermal growth factor receptor.

Reproduced from: Anders CK, Carey LA. Biology, Metastatic Patterns, and Treatment of Patients with Triple-Negative Breast Cancer. Clin Breast Cancer 2009; 9:S73. Table used with the permission of Elsevier Inc. All rights reserved.

Graphic 81333 Version 1.0

خرید پکیج

Immunophenotypic and pathologic features of triple negative breast cancer