Causes of hyperuricemia due to increased purine biosynthesis and/or urate production

Inherited enzyme defects leading to purine overproduction (rare monogenic disorders)

Hypoxanthine-guanine phosphoribosyltransferase deficiency

Phosphoribosylpyrophosphate synthetase overactivity

Glucose-6-phosphatase deficiency (glycogen storage disease, type I)

Clinical disorders leading to purine and/or urate overproduction

Myeloproliferative disorders

Lymphoproliferative disorders

Hemolytic disorders

Psoriasis

Tissue hypoxia

Down syndrome

Glycogen storage diseases (types III, V, VII)

Drug- and diet-induced purine and/or urate overproduction

Excessive ethanol ingestion

Excessive dietary purine ingestion

Excessive fructose ingestion

Cytotoxic drugs

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