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Guidelines for the evaluation of pulmonary tuberculosis in adults in five clinical scenarios

Guidelines for the evaluation of pulmonary tuberculosis in adults in five clinical scenarios
Patient and setting Recommended evaluation
Any patient with a cough of ≥2 to 3 weeks' duration, with at least one additional symptom, including fever, night sweats, weight loss, or hemoptysis Chest radiograph: If suggestive of TB*, collect three sputum specimens for AFB smear microscopy and culture. At least one specimen should also be tested using an NAA test.
Any patient at high risk for TB with an unexplained illness, including respiratory symptoms, of ≥2 to 3 weeks' duration Chest radiograph: If suggestive of TB*, collect three sputum specimens for AFB smear microscopy and culture. At least one specimen should also be tested using an NAA test.
Any patient with HIV infection and unexplained cough and fever Chest radiograph, and collect three sputum specimens for AFB smear microscopy and culture. At least one specimen should also be tested using an NAA test.
Any patient at high risk for TB with a diagnosis of community-acquired pneumonia who has not improved after seven days of treatment Chest radiograph, and collect three sputum specimens for AFB smear microscopy and culture. At least one specimen should also be tested using an NAA test.
Any patient at high risk for TB with incidental findings on chest radiograph suggestive of TB even if symptoms are minimal or absentΔ Review of previous chest radiographs if available, three sputum specimens for AFB smear microscopy and culture. At least one specimen should also be tested using an NAA test.

TB: tuberculosis; AFB: acid-fast bacilli; NAA: nucleic acid amplification.

* Infiltrates with or without cavitation in the upper lobes or the superior segments of the lower lobes.

¶ Patients with one of the following characteristics: recent exposure to a person with a case of infectious TB; history of a positive test result for Mycobacterium tuberculosis; HIV infection; injection or noninjection drug use; foreign birth and immigration from a region in which incidence is high; residents and employees of high-risk congregate settings; membership in a medically underserved, low-income population; or a medical risk factor for TB (including diabetes mellitus, conditions requiring prolonged corticosteroid and other immunosuppressive therapy, chronic renal failure, certain hematological malignancies and carcinomas, weight >10% below ideal body weight, silicosis, gastrectomy, or jejunoileal bypass).

Δ Chest radiograph performed for any reason, including targeted testing for latent TB infection and screening for TB disease.
Adapted from: Controlling tuberculosis in the United States. Recommendations from the American Thoracic Society, CDC, the Infectious Diseases Society of America. MMWR Recomm Rep 2005; 54(RR-12):1. Daley CL, Gotway MB, Jasmer RM. Radiographic manifestations of tuberculosis: a primer for clinicians. San Francisco, CA: Francis J Curry National Tuberculosis Center; 2003: 1-30, and Updated guidelines for the use of nucleic acid amplification tests in the diagnosis of tuberculosis. MMWR Morb Mortal Wkly Rep 2009; 58:7.
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