Classification of neutrophilia

Spurious

Platelet clumping

Mixed cryoglobulinemia

Primary (no other evident associated disease)

Myeloproliferative neoplasms (eg, CML, PV, ET)

Genetic/inherited conditions

Leukocyte adhesion deficiency

Chronic neutrophilic leukemia

Down syndrome

Cryoporin-associated periodic syndromes

Secondary

Infection

Inflammation (eg, autoimmune conditions, non-hematologic malignancies)

Medications

Glucocorticoids

Recombinant G-CSF or GM-CSF*

Catecholamines (epinephrine)

Lithium

All-trans retinoic acid

Isolated case reports for occasional other drugs

Asplenia/hyposplenism

Cigarette smoking

Stress (physical or emotional stress, vigorous exercise, heatstroke)

Most commonly encountered causes of neutrophilia are shown in bold.

CML: chronic myeloid leukemia; PV: polycythemia vera; ET: essential thrombocythemia; G-CSF: granulocyte colony-stimulating factor; GM-CSF: granulocyte-macrophage colony-stimulating factor.
* These agents are used therapeutically to raise the neutrophil count.

Graphic 80503 Version 6.0

خرید پکیج

Classification of neutrophilia