Hematologic diseases characterized by abnormal red cell ion transport

Disease	Transport abnormality
Sickle cell syndromes	Cellular dehydration mediated by increases in K-Cl cotransport and activity of the calcium-activated (Gardos) potassium channel
Beta thalassemia	Relative cellular dehydration mediated by K-Cl cotransport
Hemoglobin C disease	Cellular dehydration mediated by increased K-Cl cotransport
Hereditary spherocytosis	Increased sodium and potassium permeability
Hereditary stomatocytosis	Hyperhydration due to increased sodium permeability or dehydration (xerocytosis) associated with enhanced potassium loss

Abnormal_red_cell_ion_trans.htm

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