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Centers for Disease Control and Prevention case definition for pertussis (Bordetella pertussis; whooping cough)

Centers for Disease Control and Prevention case definition for pertussis (Bordetella pertussis; whooping cough)
Clinical criteria
Cough illness lasting ≥2 weeks, without a more likely diagnosis and at least one of the following:
  • Paroxysms of coughing, or
  • Inspiratory whoop, or
  • Posttussive vomiting, or
  • Apnea (with or without cyanosis)
Laboratory criteria
Isolation of Bordetella pertussis from a clinical specimen
Positive PCR for B. pertussis
Epidemiologic linkage
Contact with a laboratory-confirmed case of pertussis*
Case classification
Confirmed
Acute cough illness of any duration with isolation of B. pertussis from a clinical specimen, or
Acute cough illness of any duration with PCR positive for pertussis
Probable
Clinical criteria (as above) and absence of a more likely diagnosis, or
Acute cough illness of any duration with at least one of the following:
  • Paroxysms of coughing
  • Inspiratory whoop
  • Posttussive vomiting
  • Apnea (with or without cyanosis)
and:
  • Contact with a laboratory-confirmed case
PCR: polymerase chain reaction.
* An illness meeting the clinical case definition should be classified as "probable" rather than "confirmed" if it occurs in a patient who has contact with a laboratory-confirmed case but does not have laboratory confirmation themselves.
Adapted from: United States Centers for Disease Control and Prevention. Pertussis/Whooping Cough (Bordetella pertussis): 2020 Case Definition. Available at: https://ndc.services.cdc.gov/case-definitions/pertussis-2020/ (Accessed on February 15, 2022).
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