Structure of eltrombopag (Promacta, Revolade, SB497115)

Eltrombopag [3'-{N'-[1-(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydropyrazol-4-ylidene]hydrazino}-2'-hydroxybiphenyl-3-carboxylic acid] has an acidic (COOH) group at one end, lipophilic (CH3) groups at the other end, and a metal chelate group in the center that create a potent, orally available non-peptide TPO receptor agonist.