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Clinical features that may indicate intracranial pathology in children and adolescents with headache

Clinical features that may indicate intracranial pathology in children and adolescents with headache
Headache characteristics
  • Headache awakens the child or occurs consistently upon awakening from sleep
  • Short or paroxysmal headache; thunderclap headache (uncommon in children)
  • Associated neurologic signs and symptoms (eg, persistent nausea/vomiting, altered mental status, ataxia, etc)
  • Headache worsened in recumbent position or by cough, micturition, defecation, or physical activity
  • Chronic progressive headache pattern
  • Change in quality, severity, frequency, or pattern of headache
  • Exclusively occipital headache
  • Lack of response to medical therapy
Patient history
  • Inability of child to describe headache (eg, young age, limited intellectual ability or communication skills)
  • Risk factor for intracranial pathology (eg, sickle cell disease, immune deficiency, malignancy or history of malignancy, coagulopathy, cardiac disease with right-to-left intracardiac shunt, head trauma, neurofibromatosis type 1, tuberous sclerosis complex, preexisting hydrocephalus or shunt)
  • Age ≤6 years
  • Personality change
  • Deterioration in school performance
  • Associated symptoms in the neck or back
Examination findings
  • Abnormal neurologic examination (eg, ataxia, weakness, diplopia, abnormal eye movements, other focal signs)
  • Papilledema or retinal hemorrhages
  • Growth abnormalities (increased head circumference, short stature or deceleration of linear growth, abnormal pubertal progression, obesity)
  • Nuchal rigidity
  • Signs of trauma
  • Cranial bruits
  • Skin lesions that suggest a neurocutaneous syndrome (neurofibromatosis, tuberosis sclerosis complex)
Data from:
  1. Lewis DW, Ashwal S, Dahl G, et al. Practice parameter: Evaluation of children and adolescents with recurrent headaches: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology 2002; 59:490.
  2. Newton RW. Childhood headache. Arch Dis Child Educ Pract Ed 2008; 93:105.
  3. Strasburger VC, Brown RT, Braverman PK, et al. Headache. In: Adolescent Medicine: A Handbook for Primary Care, Lippincott Williams & Wilkins, Philadelphia 2006. p.25.
  4. Wilne S, Koller K, Collier J, et al. The diagnosis of brain tumours in children: A guideline to assist healthcare professionals in the assessment of children who may have a brain tumour. Arch Dis Child 2010; 95:534.
  5. Seshia SS, Abu-Arafeh I, Hershey AD. Tension-type headache in children: The Cinderella of headache disorders! Can J Neurol Sci 2009; 36:687.
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