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Immunogenicity of candidate conjugate vaccines against Group B streptococcus in healthy women of childbearing age

Immunogenicity of candidate conjugate vaccines against Group B streptococcus in healthy women of childbearing age
Type Ia-TT and Ib-TT conjugate vaccines were well tolerated by healthy, childbearing-age women, and the serotype-specific IgG response was significantly greater in recipients of the conjugate compared with the uncoupled CPS vaccine. Subjects were randomized to receive (panel A) Ia-TT vaccine (red line, n = 30), uncoupled Ia CPS (blue line, n = 30), or saline placebo (green line, n = 15); or (panel B) Ib-TT vaccine (red line, n = 30), uncoupled Ib CPS (blue line, n = 15), or saline placebo (green line, n = 10).
CPS: capsular polysaccharide; TT: tetanus toxoid.
Data from: Baker CJ, Paoletti LC, Wessels MR, et al. J Infect Dis 1999; 179:142.
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