Cell type | Age-related decrease | Age-related increase | No change |
Thymic precursors | Thymus size Number of thymic precursors | ||
T lymphocytes | Number of naïve T cells Diversity of T cell repertoire Proliferative capacity Signaling intensity Regulatory T cell function | ||
B lymphocytes | B cells precursors in the bone marrow (pre-B cells) Peripheral B cell numbers B cell repertoire Antibody response Opsonizing capacity of immunoglobulins | Autoreactive serum antibodies | Immunoglobulin levels (may increase) |
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