Histologic scoring of gastric marginal zone lymphoma

Grade	Description	Histologic features
0	Normal	Scattered plasma cells in lamina propria; no lymphoid follicles
1	Chronic active gastritis	Small clusters of lymphocytes in lamina propria; no lymphoid follicles; no LELs
2	Chronic active gastritis with florid lymphoid follicle formation	Prominent lymphoid follicles with surrounding mantle zone and plasma cells; no LELs
3	Suspicious lymphoid infiltrate in lamina propria, probably reactive	Lymphoid follicles surrounded by small lymphocytes that infiltrate diffusely in lamina propria and occasionally into epithelium
4	Suspicious lymphoid infiltrate in lamina propria, probably lymphoma	Lymphoid follicles surrounded by CCL cells that infiltrate diffusely in lamina propria and into epithelium in small groups
5	Marginal zone lymphoma	Presence of dense diffuse infiltrate of CCL cells in lamina propria with prominent LELs

CCL: centrocyte-like lesion; LEL: lymphoepithelial lesion.

Adapted from: Wotherspoon AC, Dogliogi C, Diss TC, et al. Lancet 1993; 342:575.

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