CARG model for predicting chemotherapy toxicity in older adults

Risk factor	Prevalence		Grades 3 to 5 toxicity		OR	95% CI	Score
Risk factor	No.	Percent	No.	Percent	OR	95% CI	Score
Age ≥72 years	270	54	163	60	1.85	1.22 to 2.82	2
Cancer type GI or GU	185	37	120	65	2.13	1.39 to 3.24	2
Chemotherapy dosing, standard dose	380	76	204	54	2.13	1.29 to 3.52	2
Number of chemotherapy drugs, polychemotherapy	351	70	192	55	1.69	1.08 to 2.65	2
Hemoglobin <11 g/dL (male), <10 g/dL (female)	62	12	46	74	2.31	1.15 to 4.64	3
Creatinine clearance (Jelliffe, ideal weight) <34 mL/min	44	9	34	77	2.46	1.11 to 5.44	3
Hearing, fair or worse	123	25	76	62	1.67	1.04 to 2.69	2
Number of falls in last six months, one or more	91	18	61	67	2.47	1.43 to 4.27	3
IADL: Taking medications, with some help/unable	39	8	28	72	1.50	0.66 to 3.38	1
MOS: Walking one block, somewhat limited/limited a lot	109	22	69	63	1.71	1.02 to 2.86	2
MOS: Decreased social activity because of physical/emotional health, limited at least sometimes	218	44	126	58	1.36	0.90 to 2.06	1

CARG: Cancer and Aging Research Group; OR: odds ratio; GI: gastrointestinal; GU: genitourinary; IADL: instrumental activities of daily living; MOS: Medical Outcomes Study.

From: Hurria A, Togawa K, Mohile SG, et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol 2011; 29:3457. Reprinted with permission. Copyright © 2011 American Society of Clinical Oncology. All rights reserved.

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CARG model for predicting chemotherapy toxicity in older adults