T cell regulation by cytokines

The figure depicts the cytokine pathways that regulate the differentiation of T cells into effector lineages of Th1, Th2, Th9, and Th17 phenotype. These in turn mediate distinct functions in regulating cell-mediated and humoral immunity.

DC: dendritic cell; CD: cluster of differentiation; MHC: major histocompatibility complex; L: ligand; TCR: T cell receptor; ICOSLG: inducible T cell costimulator ligand;Th: T helper cell; IL: interleukin; TGF-beta1: transforming growth factor beta 1; IFN-gamma: interferon gamma; TNF-alpha: tumor necrosis factor alpha.

Graphic 78712 Version 8.0

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T cell regulation by cytokines