Risk stratification of myeloma

High risk	Standard risk
17p13 deletion t(4;14) t(14;16) t(14;20) Gain or amplification 1q LDH ≥2 times institutional upper limit of normal Features of primary plasma cell leukemia* High-risk gene expression profiling signature^¶	All others including those with: Trisomies (hyperdiploidy) t(11;14) t(6;14)

The definition of high-risk disease continues to evolve based on available evidence. To risk-stratify myeloma patients at initial diagnosis we perform fluorescence in situ hybridization (FISH) studies on the bone marrow for t(11;14), t(4;14), t(6;14), t(14;16), t(14;20), del17p13, gain 1q, and trisomies of odd numbered chromosomes.

LDH: lactate dehydrogenase.

* Defined by ≥5% circulating plasma cells on a manual differential count of the peripheral blood.

¶ While patients with a high-risk signature on gene expression profiling are considered to have high-risk myeloma, this test is not recommended on a routine basis.

Graphic 78344 Version 16.0

خرید پکیج

Risk stratification of myeloma