Stages of opioid withdrawal syndrome

Stage	Features
Stage I: Up to 8 hours	Fear of withdrawal, anxiety, drug craving
Stage II: 8-24 hours	Insomnia, restlessness, anxiety, yawning, stomach cramps, lacrimation, rhinorrhea, diaphoresis, mydriasis
Stage III: Up to 3 days	Vomiting, diarrhea, fever, chills, muscle spasms, tremor, tachycardia, piloerection, hypertension, seizures*

* Only seen in neonates.

Graphic 78321 Version 4.0

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