Causes of peripheral lymphadenopathy*

Cause	Examples
Infections
Bacterial
Localized	Streptococcal pharyngitis; skin infections; tularemia; plague; cat scratch disease; diphtheria; chancroid; rat bite fever; early Lyme disease; early (primary) syphilis
Generalized	Brucellosis; leptospirosis; lymphogranuloma venereum; typhoid fever; secondary syphilis
Viral	Human immunodeficiency virus; Epstein-Barr virus; herpes simplex virus; cytomegalovirus; mumps; measles; rubella; hepatitis B; dengue fever
Mycobacterial	Mycobacterium tuberculosis; atypical mycobacteria
Fungal	Histoplasmosis; coccidioidomycosis; cryptococcosis
Protozoal	Toxoplasmosis; leishmaniasis
Cancer	Squamous cell cancer of the head and neck; metastatic skin cancer (face and scalp); metastatic cancer from another site; lymphoma; leukemia
Lymphoproliferative	Angioimmunoblastic lymphadenopathy with dysproteinemia
	Autoimmune lymphoproliferative disease
	Rosai-Dorfman disease
	Hemophagocytic lymphohistiocytosis
Immunologic	Serum sickness; drug reactions (phenytoin); IgG4-related disease
Endocrine	Primary adrenal insufficiency (Addison's disease)
Miscellaneous	Sarcoidosis; lipid storage diseases; amyloidosis; histiocytosis; chronic granulomatous diseases; Castleman disease; Kikuchi disease; Kawasaki disease; inflammatory pseudotumor; systemic lupus erythematosus; rheumatoid arthritis; Still's disease; dermatomyositis; eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

IgG4: immunoglobulin G4.
* NOTE: This is a partial list and is not meant to be all-inclusive.

Graphic 77382 Version 10.0