Usual doses of antileukotriene agents in the management of persistent asthma

Medication	Preparations	Infant and small child	Pediatric	Adolescent and adult
Montelukast	Granules: 4 mg per packet Chewable tablets: 4 mg, 5 mg Tablet: 10 mg	12 months* to 5 years: 4 mg granules or chewable tablet once daily in evening	6 to 14 years: 5 mg chewable tablet once daily in evening	≥15 years and adult: 10 mg tablet once daily in evening
Zafirlukast^¶	Tablets: 10 mg, 20 mg	(Not studied)	5 to 11 years: 10 mg twice per day	≥12 years and adult: 20 mg twice per day
Zileuton^¶	Immediate-release tablet: 600 mg Extended-release tablet: 600 mg	(Not studied)	(Not studied)	≥12 years and adult: Immediate release: 600 mg four times per day Extended release: 1200 mg twice per day
Pranlukast^Δ	Capsules: 112.5 mg, 225 mg Granules: 50 mg, 70 mg, 100 mg per packet	24 months to 5 years: 7 to 10 mg/kg granules per day in two divided doses	6 to 11 years: 7 to 10 mg/kg per day granules in two divided doses (maximum 225 mg twice per day)	≥12 years and adult: 225 mg twice per day

* Approved for use in infants ≥6 months in some countries other than United States.
¶ Elevated transaminases and severe hepatoxicity have been reported.
Δ Not available in United States. Available in Japan, Mexico, Venezuela, Turkey, and Korea.

Data from:

US Food & Drug Administration approved prescribing information. Available at https://dailymed.nlm.nih.gov/dailymed/ (Accessed September 20, 2020).
Bisgaard H, et al. Pediatric Pulmonol 2009; 44:568.
Keam SJ, et al. Drugs 2003; 63:991.

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خرید پکیج

Usual doses of antileukotriene agents in the management of persistent asthma