Electron micrograph type 3 membranoproliferative glomerulonephritis

Electron micrograph in type 3 membranoproliferative glomerulonephritis (MPGN) shows marked thickening (more than three times normal) of the glomerular capillary wall and complex disruption of the glomerular basement membrane with large lucent areas (arrows) and variable decrease in thickness of the lamina densa (LD). A red cell is present in the capillary lumen.

Electron micrograph of a normal glomerular capillary loop showing the fenestrated endothelial cell (Endo), the glomerular basement membrane (GBM), and the epithelial cells with its interdigitating foot processes (arrow). The GBM is thin, and no electron-dense deposits are present. Two normal platelets are seen in the capillary lumen.