ﺑﺎﺯﮔﺸﺖ ﺑﻪ ﺻﻔﺤﻪ ﻗﺒﻠﯽ
خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
medimedia.ir

Cytochrome P450 3A (including 3A4) inhibitors and inducers

Cytochrome P450 3A (including 3A4) inhibitors and inducers
Strong inhibitors Moderate inhibitors Strong inducers Moderate inducers
  • Adagrasib
  • Atazanavir
  • Ceritinib
  • Clarithromycin
  • Cobicistat and cobicistat-containing coformulations
  • Darunavir
  • Idelalisib
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Levoketoconazole
  • Lonafarnib
  • Lopinavir
  • Mifepristone*
  • Nefazodone
  • Nelfinavir
  • Nirmatrelvir-ritonavir
  • Ombitasvir-paritaprevir-ritonavir
  • Ombitasvir-paritaprevir-ritonavir plus dasabuvir
  • Posaconazole
  • Ritonavir and ritonavir-containing coformulations
  • Saquinavir
  • Tucatinib
  • Voriconazole
  • Amiodarone
  • Aprepitant
  • Berotralstat
  • Cimetidine
  • Conivaptan
  • Crizotinib
  • Cyclosporine
  • Diltiazem
  • Duvelisib
  • Dronedarone
  • Erythromycin
  • Fedratinib
  • Fluconazole
  • Fosamprenavir
  • Fosaprepitant
  • Fosnetupitant-palonosetron
  • Grapefruit juice
  • Imatinib
  • Isavuconazole (isavuconazonium sulfate)
  • Lefamulin
  • Letermovir
  • Netupitant
  • Nilotinib
  • Ribociclib
  • Schisandra
  • Verapamil
  • Apalutamide
  • Carbamazepine
  • Encorafenib
  • Enzalutamide
  • Fosphenytoin
  • Lumacaftor
  • Lumacaftor-ivacaftor
  • Mitotane
  • Phenobarbital
  • Phenytoin
  • Primidone
  • Rifampin (rifampicin)
  • Bexarotene
  • Bosentan
  • Cenobamate
  • Dabrafenib
  • DexamethasoneΔ
  • Dipyrone
  • Efavirenz
  • Elagolix, estradiol, and norethindrone therapy pack
  • Eslicarbazepine
  • Etravirine
  • Lorlatinib
  • Mitapivat
  • Modafinil
  • Nafcillin
  • Pexidartinib
  • Repotrectinib
  • Rifabutin
  • Rifapentine
  • Sotorasib
  • St. John's wort
  • For drug interaction purposes, the inhibitors and inducers of CYP3A metabolism listed above can alter serum concentrations of drugs that are dependent upon the CYP3A subfamily of liver enzymes, including CYP3A4, for elimination or activation.
  • These classifications are based upon US Food and Drug Administration (FDA) guidance.[1,2] Other sources may use a different classification system resulting in some agents being classified differently.
  • Data are for systemic drug forms. Degree of inhibition or induction may be altered by dose, method, and timing of administration.
  • Weak inhibitors and inducers are not listed in this table with exception of a few examples. Clinically significant interactions can occasionally occur due to weak inhibitors and inducers (eg, target drug is highly dependent on CYP3A4 metabolism and has a narrow therapeutic index). Accordingly, specific interactions should be checked using a drug interaction program such as the Lexicomp drug interactions program included within UpToDate.
  • Refer to UpToDate topics on specific agents and indications for further details.

* Mifepristone is a significant inhibitor of CYP3A4 when used chronically (eg, for hyperglycemia in patients with Cushing syndrome); not in single-dose use.

¶ Classified as a weak inhibitor of CYP3A4 according to FDA system.[1]

Δ Classified as a weak inducer of CYP3A4 according to FDA system.[1]

◊ The fixed-dose combination therapy pack taken in the approved regimen has moderate CYP3A4 induction effects. When elagolix is used as a single agent, it is a weak CYP3A4 inducer. Norethindrone and estradiol are not CYP3A4 inducers.

Data from: Lexicomp Online (Lexi-Interact). Copyright © 1978-2024 Lexicomp, Inc. All Rights Reserved.

References:
  1. Clinical Drug Interaction Studies — Cytochrome P450 Enzyme- and Transporter-Mediated Drug Interactions Guidance for Industry (January 2020) available at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/clinical-drug-interaction-studies-cytochrome-p450-enzyme-and-transporter-mediated-drug-interactions.
  2. US Food & Drug Administration. Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: FDA.gov website.
Graphic 76992 Version 98.0

آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟