Version May 2024
| Drug | Estimated minimum fatal dose | Major effects |
| Benzocaine (eg, Orajel) | <20 mg/kg | Methemoglobinemia, seizures |
| Beta blockers | Unclear | Seizures, hypoglycemia, bradycardia, hypotension |
| Calcium antagonists | <40 mg/kg | Bradycardia, hypotension |
| Camphor | Approximately 50 mg/kg | Seizures, CNS depression, respiratory depression |
| Chloroquine | <30 mg/kg | Seizures, arrhythmias |
| Clonidine | Unclear | Bradycardia, hypotension, CNS depression |
| Diphenoxylate (eg, Lomotil) | 1.2 mg/kg | CNS depression, respiratory depression |
| Imidazoline-derived sympathomimetics (eg, Visine, Afrin) | Unclear | Lethargy, miosis, hypotension, bradycardia, respiratory depression, shock |
| Lindane | Approximately 6 mg/kg | Seizures, CNS depression |
| Methadone | Approximately 5 mg/kg | CNS depression, respiratory depression |
| Methyl salicylate | Approximately 200 mg/kg | Seizures, acidosis, cardiovascular collapse |
| Nicotine (liquid)[6] | 1 to 3 mg/kg | Seizures, coma, respiratory arrest, cardiac arrest |
| Opioids (eg, methadone, long-acting morphine) | Unknown | Miosis, CNS depression, respiratory depression |
| Phenothiazines | Approximately 20 mg/kg | Seizures, arrhythmias, CNS depression |
| Phenylpropanolamine | Unclear | Arrhythmia, intracranial bleed |
| Quinidine | Approximately 50 mg/kg | Seizures, arrhythmia, CNS depression |
| Quinine | Approximately 80 mg/kg | Seizures, arrhythmias, retinal injury |
| Sulfonylureas | <1 mg/kg | Hypoglycemia |
| Theophylline | Approximately 50 mg/kg | Seizures, arrhythmias |
| Tricyclic antidepressants | Approximately 15 mg/kg | Seizures, arrhythmias, hypotension |
| Toxic alcohols (eg, methanol, ethylene glycol) | 0.3 mL/kg | CNS depression |
| Vilazodone[7] | 10 mg (1 pill) | Seizures, coma, tachycardia |
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