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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Intensive treatment for Burkitt leukemia/lymphoma: CALGB 9251 (revised*)

Intensive treatment for Burkitt leukemia/lymphoma: CALGB 9251 (revised*)
Cycle 1
Cyclophosphamide: 200 mg/m2 IV per day on days 1 through 5
Prednisone: 60 mg/m2 PO per day on days 1 through 7
Cycles 2, 4, and 6
Ifosfamide: 800 mg/m2 over one hour IV per day on days 1 through 5
Mesna: 200 mg/m2 IV per day on days 1 through 5 at 0, 4, and 8 hours after ifosfamide
Methotrexate: 150 mg/m2 IV over 30 minutes on day 1, then 1.35 g/m2 IV over the next 23.5 hours, for a total dose of 1.5 g/m2
Leucovorin: 50 mg/m2 IV 36 hours after initiation of methotrexate, then 15 mg/m2 every 6 hours until serum methotrexate concentration <0.05 micromolar
Vincristine: 2 mg IV push on day 1
Cytarabine: 150 mg/m2 per day by continuous IV infusion on days 4 and 5
Etoposide: 80 mg/m2 per day IV over one hour on days 4 and 5
Dexamethasone: 10 mg/m2 PO per day on days 1 through 5
Cycles 3, 5, and 7
Cyclophosphamide: 200 mg/m2 per day IV on days 1 through 5
Methotrexate: 150 mg/m2 IV over 30 minutes on day 1, then 1.35 g/m2 IV over the next 23.5 hours, for a total dose of 1.5 g/m2
Leucovorin: 50 mg/m2 IV 36 hours after initiation of methotrexate, then 15 mg/m2 every 6 hours until serum methotrexate concentration <0.05 micromolar
Vincristine: 2 mg IV push on day 1
Doxorubicin: 25 mg/m2 per day by IV bolus on days 4 and 5
Dexamethasone: 10 mg/m2 PO per day on days 1 through 5
Intrathecal chemotherapy with cycles 2 through 7 (amended)
Methotrexate: 15 mg IT on day 1
Cytarabine: 40 mg IT on day 1
Hydrocortisone: 50 mg IT on day 1
Cranial irradiation (amended)
2400 cGy administered in 12 fractions after chemotherapy for cycle 7 completed, only for patients who had prior bone marrow involvement at the time of presentation
CALGB: Cancer and Leukemia Group B; IV: intravenously; PO: by mouth; IT: intrathecal injection.
* Revised protocol as given to Cohort 2 of the study in order to reduce the incidence and severity of neurotoxicity.
¶ All cycles are repeated at 21-day intervals except cycle 1, which lasts 7 days.
Modified from: Lee, EJ, et al. J Clin Oncol 2001; 19:4014 and Rizzieri, DA, et al. Cancer 2004; 100:1438.
Graphic 76650 Version 4.0

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