Clinical variants of multiple keratoacanthomas

Type	Characteristics	Genetic features
Generalized eruptive keratoacanthomas of Grzybowski	Presents in fifth to seventh decade Multiple follicular-based papules and ulcerated nodules 100s to 1000s of lesions Predilection for the trunk, extremities, and inner mouth Disfigurement due to facial lesions (ectropion) Individual lesions spontaneously regress with scar formation	Sporadic disorder
Multiple self-healing squamous epithelioma (Ferguson-Smith disease)	Present in second to third decade; mean age of 25 Multiple reddish macules that develop into papules and nodules that resemble solitary keratoacanthoma Single lesion to 100s in number Predilection for sites of trauma and sun-exposed areas, face, arms Individual lesions involute spontaneously, but lesions may recur throughout life	Autosomal dominant Loss of function mutations in TGFBR1 gene Increased in patients with Scottish ancestry
Multiple familial keratoacanthoma of Witten and Zak	Clinical features of both generalized eruptive keratoacanthomas of Grzybowski and multiple self-healing squamous epithelioma Larger lesions that tend to ulcerate Locally destructive
Muir-Torre syndrome	May occur in both young and older patients Multiple keratoacanthomas Sebaceous tumors Visceral malignancies (genitourinary and gastrointestinal)	Autosomal dominant Defect in mismatch repair gene (MSH2 or MLH1)

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