Patterns of peripheral blood lymphocyte levels

Defective protein	CD4	CD8	B cell	NK cell
RAG1/RAG2	↓	↓	↓	NL
MHCII	↓	NL	NL	NL
CD3 delta	↓	↓	NL/↑	NL/↑
CD3 gamma	↓	↓	NL	NL
CD3 epsilon	↓	↓	NL	NL
CD3 zeta	↓	↓/NL	NL	NL
p56lck	↓	NL/↑	NL	NL
ZAP-70	NL/↑	↓	NL	↓/NL

CD4: cluster of differentiation 4; CD8: cluster of differentiation 8; NK: natural killer; RAG: recombinase-activating gene; MHCII: major histocompatibility complex II; CD3: cluster of differentiation 3; p56lck: lymphocyte-specific protein-tyrosine kinase; ZAP-70: zeta-chain-associated protein kinase 70 kilodalton; NL: normal.

Graphic 76313 Version 2.0

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