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Effects of lipid-lowering drugs on serum lipid levels

Effects of lipid-lowering drugs on serum lipid levels
Drug Serum LDL-C
(% change)		 Serum HDL-C
(% change)		 Serum triglycerides
(% change)
Bile acid sequestrants ↓ 15 to 30 0 to slight increase No change or increase
Ezetimibe ↓ 17 ↑ 1 ↓ 7 to 8
Fenofibrate (micronized form) ↓ 6 to 20 ↑ 5 to 20* ↓ 41 to 53
Gemfibrozil ↓ 10 to 15 ↑ 5 to 20* ↓ 35 to 50
Nicotinic acid (niacin) ↓ 10 to 25 ↑ 15 to 35 ↓ 25 to 30
Marine omega-3 fatty acidsΔ Variable ↑ 5 to 9 ↓ 23 to 45
PCSK9 inhibitors ↓ 38 to 72 ↑ 4 to 9 ↓ 2 to 23
Statins ↓ 20 to 60 ↑ 5 to 10 ↓ 10 to 33
Bempedoic acid ↓ 15 to 19 No change to ↓ 4.5 No change
LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; ↑: increase; ↓: decrease; PCSK9 inhibitors: proprotein convertase subtilisin/kexin type 9 inhibitors.
* Increases of 20% are seen in patients with very high triglycerides; increases of 5% are more typical with fibrate monotherapy in patients with lower triglycerides.
¶ When used for the treatment of hypertriglyceridemia, LDL-C may increase.
Δ 4 g daily of highly purified preparations or 12 to 15 g of less purified forms of marine omega-3 fatty acids.
Graphic 75715 Version 17.0

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