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Typical clinical course of Escherichia coli O157:H7 infections

Typical clinical course of Escherichia coli O157:H7 infections
About three days after ingestion of the organism, the patient develops diarrhea, abdominal pain, fever, and vomiting. The diarrhea becomes bloody one to three days later, rarely on the first day. In 80 to 90 percent of infected children with positive cultures, visible blood is present in the stools. When bloody diarrhea first develops, the patient has a normal platelet count, creatinine concentration, and packed-cell volume, with no red cell fragmentation. However, if studies of the coagulation and fibrinolytic systems are done early in the illness, there is evidence that thrombin generation is increased, fibrin deposition is occurring, and plasminogen activation is suppressed.
HUS: hemolytic uremic syndrome.
Reproduced with permission from: Tarr PI, Gordon CA, Chandler WL. Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome. Lancet 2005; 365:1073. Copyright ©2005 Elsevier.
Graphic 75352 Version 4.0

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