Leukotriene modifiers

PLA₂: phospholipase A₂; AA: arachidonic acid; 5-LO: 5-lipoxygenase; FLAP: 5-LO activating protein; LTA₄: leukotriene A₄; LTA₄H: LTA₄ hydrolase; LTC₄S: LTC₄ synthetase; LTB₄: leukotriene B₄ arises from the hydrolysis of LTA₄ by LTA₄ hydrolase; LTC₄: leukotriene C₄ arises from the conjugation of LTA₄ with reduced glutathione by LTC₄ synthetase; LTD₄: leukotriene D₄ arises from LTC₄ by the rapid removal of glutamic acid in the extracellular microenvironment; LTE₄: leukotriene E₄ arises from LTD₄ by the further removal of glycine in the extracellular microenvironment; BLT1: receptor for LTB₄, no commercially available inhibitors; BLT2: receptor for LTB₄, no commercially available inhibitors; CysLTS: cys-leukotrienes, LTC₄, LTD₄, LTE₄; CysLT1: receptor for LTC₄, LTD₄, LTE₄, inhibited by montelukast, pranlukast, and zafirlukast; CysLT2: receptor for LTC₄, LTD₄, LTE₄, but not inhibited by montelukast, pranlukast, or zafirlukast.