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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Comparison of different intravenous lipid emulsion formulations used in infants and children

Comparison of different intravenous lipid emulsion formulations used in infants and children
  Intralipid
(Fresenius Kabi)		 Nutrilipid
(B. Braun)		 Omegaven*
(Fresenius Kabi)		 Smoflipid
(Fresenius Kabi)
Concentrations (percent) 10, 20 20 10 20
Oil source (percent) Soybean 100 Soybean 100 Fish 100

Soybean 30

MCT 30

Olive 25

Fish 15
Fatty acids (percent)
Linoleic (C 18:2 ω-6) 44 to 62 48 to 58 1 to 7 18.7
Linolenic (C 18:3 ω-3) 4 to 11 4 to 11 2 2.4
Palmitic (C 16:0) 7 to 14 9 to 13 2.5 to 10 9.2
Oleic (C 18:1 ω-9) 19 to 30 17 to 30 6 to 13 27.8
Stearic (C 18:0) 1.4 to 5.5 2.5 to 5 0.5 to 2 2.7
EPA (C 20:5 ω-3) 0 0 12.5 to 28.2 2.4
DHA (C 22:6 ω-3) 0 0 14.4 to 30.9 2.2
Caprylic acid (C 8:0) 0 0 0 16.3
Caproic acid (C 10:0) 0 0 0 11.4
Ratio (ω-6:ω-3) 7:1 Not available 1:7 2.5:1
Egg yolk phospholipids (percent) 1.2 1.2 1.2 1.2
Glycerin (percent) 2.25, 2.25 2.5 2.5 2.5
Energy density (kcal/mL) 1.1, 2 2 1.1 2
Osmolarity (mOsm/L) 260, 260 390Δ 308 to 376Δ 380Δ
Approved product labeling in the United States and other countries warns of risks of hyperlipidemia, fat accumulation in lungs, and potential aluminum toxicity with use of intravenous fat emulsions in preterm and very low birth weight infants. Refer to accompanying UpToDate topic text and local product information.

MCT: medium-chain triglycerides; DHA: docosahexaenoic acid; EPA: eicosapentaenoic acid; PUFA: long-chain n-3 polyunsaturated fatty acids.

* Omegaven fish oil contains several other n-3 PUFAs and arachidonic acid, in addition to those shown in this table. Additional information is available from the Oley Foundation website.

¶ For fatty acids, the percentages shown are based on the lipid component of emulsion only. Thus, for a 10% lipid emulsion, the final concentration (ie, grams per 100 mL) is obtained by dividing each fatty acid percent shown in the table by 10. The chemical structure is noted as: length of hydrocarbon chain (C atoms): number of double bonds; and position of first double bond (ω).

Δ mOsm/kg.
Data from:
  1. Gura KM, Duggan CP, Collier SB, et al. Reversal of parenteral nutrition - associated liver disease in two infants with short bowel syndrome using parenteral fish oil: implications for future management. Pediatrics 2006; 118:197.
  2. Nordenström J, Thörne A. Comparative studies on a new concentrated fat emulsion: intralipid 30 percent vs. 20 percent. Clin Nutr 1993; 12:160.
  3. Smoflipid (lipid injectable emulsion) United States product information. 2022. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/207648s005lbl.pdf (Accessed on March 31, 2022).
  4. Rayvan M, Devliger H, Jochum F, et al. Short-term use of parenteral nutrition with a lipid emulsion containing a mixture of soybean oil, olive oil, medium-chain triglycerides and fish oil: A randomized double-blind study in preterm infants. J Parenter Enteral Nutr 2012; 36:81S.
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