Endoscopic findings in Crohn disease

The dominant endoscopic feature in Crohn disease is the presence of ulcerations. Endoscopic findings in Crohn disease include: aphthous ulcers, which are the earliest lesions seen in Crohn disease (panel A); large ulcers interspersed with normal mucosa, which are typical for the segmental distribution of Crohn disease (panel B); a cobblestone appearance that is characterized by nodular thickening, with linear or serpiginous ulcers (panel C); and strictures due to fibrosis (panel D).