Calculate total score – Add individual scores for each laboratory parameter
≥5 – Compatible with overt DIC. Repeat scoring daily.
<5 – Suggestive (not affirmative) for non-overt DIC. Repeat in 1 to 2 days.
DIC: disseminated intravascular coagulation; FDPs: fibrin degradation products; PT: prothrombin time. * Causes of DIC in children include infection, trauma, burns, malignancy, acute and chronic liver disease (including Reye syndrome), microangiopathic disorders (eg, Kasabach-Merritt syndrome), and congenital thrombotic disorders (eg, homozygous deficiencies of protein C and S, antithrombin III deficiency). Additional causes in neonates include birth asphyxia, respiratory distress syndrome, meconium aspiration, amniotic fluid aspiration, and necrotizing enterocolitis. ¶ Although D-dimer is not explicitly included in this scoring system, elevated D-dimer is a strong indicator of fibrinolysis and is more specific than FDPs.