Version June 2024
| Markers of good prognosis |
| Low Rai or Binet clinical stage |
| Interstitial or nodular pattern of lymphocyte infiltration in marrow |
| Lymphocyte doubling time >12 months |
| CD38 negativity |
| Mutated immunoglobulin Vh genes |
| ZAP-70 negativity (low levels) |
| Del 13q14 |
| Markers of poor prognosis |
| High Rai or Binet stages |
| Diffuse pattern of lymphocyte marrow infiltration |
| Lymphocyte doubling time <12 months |
| CD38 positivity |
| Unmutated immunoglobulin Vh genes |
| ZAP-70 positivity (high levels) |
| Del 11q23 |
| 17p-/p53 abnormalities |
| TP53 dysfunction or increased expression |
| Increased levels of TNF-alpha, beta-2 microglobulin, IL-6, IL-8, IL-10, LDH, VEGFR-2, CD20, and CD52 |
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