Accelerated follicular atresia |
Genetic defects |
- Karyotype abnormalities (X chromosome deletions and translocations including Turner syndrome)
- Autosomal gene mutations affecting meiosis, transcription, or translation
- Autosomal gene mutations affecting metabolism (galactosemia, mitochondrial function)
- Repeat expansion disorders (FMR1)
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Ovarian toxins |
- Chemotherapeutic drugs (especially alkylating agents)
- Radiation
- Mumps or cytomegalovirus infection
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Autoimmune injury |
- Isolated or part of polyglandular autoimmune syndromes
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Abnormal follicular stimulation |
Intraovarian modulators |
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Steroidogenic enzyme defects |
- CYP17 deficiency, StAR mutation
- Aromatase gene mutations
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Gonadotropin receptor function |
- FSH receptor mutations
- Gs alpha subunit gene mutations
- Gonad and adrenal development – NR5A1
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