Adrenal androgen production declines with age

Urinary 17-ketosteroid excretion and DHEA-S concentrations as a function of age in normal women. There is a progressive decline in both measurements after age 20 years.

DHEA-S: dehydroepiandrosterone sulfate.

Data from: Zumoff B, Rosenfield RS, Strain GW, et al. Sex differences in the twenty-four-hour mean plasma concentrations of dehydroisoandrosterone (DHA) and dehydroisoandrosterone sulfate (DHAS) and the DHA to DHAS ratio in normal adults. J Clin Endocrinol Metab 1980; 51:330.

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Adrenal androgen production declines with age