Version May 2024
| Drug | Mechanism(s) |
| Abciximab | DITP |
| Aceclofenac | DITP |
| Acetaminophen | DITP; antibodies react with a drug metabolite, not the unmodified drug |
| Alemtuzumab | ITP* |
| Amiodarone | DITP |
| Aspirin | DITP |
| Atezolizumab | DITP |
| Aztreonam | DITP |
| Beta-lactam antibiotics (penicillins, cephalosporins, flucloxacillin) | DITP |
| Bisoprolol | DITP |
| Carbamazepine | DITP |
| Ceftriaxone | DITP |
| Cetirizine | DITP |
| COVID-19 vaccines | ITP, VITT (only adenoviral-vectored vaccines are known to cause VITT) |
| Daptomycin | Bone marrow suppression (dose-dependent) and DITP |
| Dexamethasone | DITP |
| Diazoxide | DITP |
| Diclofenac | DITP |
| Diltiazem | DITP |
| Durvalumab | DITP |
| Eptifibatide | DITP |
| Ethambutol | DITP |
| Ethosuximide | DITP |
| Exenatide | DITP |
| Felbamate | DITP |
| Fluorouracil | DITP |
| Furosemide | DITP |
| Gold compounds | DITP that may persist after the drug is stopped |
| Haloperidol | DITP |
| Heparin | Drug-dependent antibodies that also activate platelets and are associated with thrombosis |
| Ibuprofen | DITP; in some patients, antibodies react with the unmodified drug; in others, antibodies only react with a drug metabolite |
| Influenza vaccine (trivalent, inactivated) | DITP |
| Intravenous immune globulin (IVIG) | DITP |
| Ipilimumab | ITP¶ |
| Irinotecan | DITP |
| Leucovorin | DITP |
| Levofloxacin | DITP |
| Linezolid | Bone marrow suppression (dose-dependent) |
| MMR vaccine | ITP |
| Mirtazapine | DITP |
| Naproxen | DITP; antibodies react with a drug metabolite, not the unmodified drug |
| Natalizumab | ITP |
| Nivolumab | ITP¶ |
| Ondansetron | DITP |
| Oseltamivir | DITP |
| Oxaliplatin | DITP |
| Palonosetron | DITP |
| Pembrolizumab | ITP¶ |
| Penicillin | DITP |
| Phenytoin | DITP |
| Piperacillin | DITP |
| Pyrazinamide | DITP |
| Quetiapine | DITP |
| Quinidine | DITP |
| QuinineΔ | DITP |
| Rifampin | DITP |
| Simvastatin | DITP |
| Sulfonamides | DITP |
| Suramin | DITP |
| Tacrolimus | DITP |
| Teicoplanin | DITP |
| Tirofiban | DITP |
| Trastuzumab | DITP |
| Trimethoprim-sulfamethoxazole | DITP; antibodies to both components have been identified |
| Valproic acid | Bone marrow suppression (dose-dependent) |
| Vancomycin◊ | DITP |
| Volanesorsen | Unknown |
This table lists drugs with evidence for a causal association with isolated thrombocytopenia; certain foods and beverages (eg, quinine-containing beverages, certain herbal teas, walnuts) can also cause thrombocytopenia. The drugs listed in this table come from clinical data in published case reports, identification of drug-dependent, platelet-reactive antibodies, or both; it also lists their mechanisms.
Criteria for evaluating reports of a drug-induced etiology include:Drugs in bold have been most commonly implicated in a causal relationship. Drug-dependent antibodies have been shown for all agents associated with DITP with the exceptions of aspirin, ethosuximide, exenatide, filgrastim, and linezolid.[1,2]
Refer to UpToDate for additional information on drug-induced thrombocytopenia.DITP: drug-induced immune thrombocytopenia, caused by drug-dependent antibodies; ITP: immune thrombocytopenia, caused by an autoimmune mechanism that no longer requires the presence of the drug; COVID-19: coronavirus disease 2019; VITT: vaccine-induced immune thrombotic thrombocytopenia; MMR: measles, mumps, and rubella.
* ITP is a rare adverse reaction to alemtuzumab. Thrombocytopenia typically presents months after alemtuzumab exposure and responds well to standard ITP therapies.
¶ Thrombocytopenia may occur when the patient is not actively on the drug; it often responds to standard ITP therapies.
Δ Quinine can also cause a thrombotic microangiopathy and/or other cytopenias.
◊ In addition to parenteral formulations, vancomycin may be present in orthopedic cement used for joint replacement.آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
