Increased DLCO |
Altitude |
Asthma |
Polycythemia |
Severe obesity |
Pulmonary hemorrhage |
Left-to-right intracardiac shunting |
Mild left heart failure - increased pulmonary capillary blood volume |
Exercise just prior to the test - increased cardiac output |
Mueller maneuver |
Supine position |
Low DLCO with normal spirometry and normal lung volume |
Anemia - mild decrease |
Pulmonary vascular disease - mild to severe decrease |
Early interstitial lung disease - mild to moderate decrease |
Valsalva maneuver |
Low DLCO with obstruction with or without concomitant restriction |
Bronchiolitis |
Combined pulmonary fibrosis and emphysema (CPFE) |
Cystic fibrosis |
Emphysema |
Interstitial lung disease in patient with COPD |
Lymphangioleiomyomatosis |
Sarcoid |
Low DLCO with restriction |
Interstitial lung disease |
Pneumonitis |
Other |
Carboxyhemoglobin - reduces DLCO |
Supplemental oxygen - reduces DLCO |
Bronchodilator - increases DLCO |
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