Skin lesion in mixed connective tissue disease

Biopsy of a skin lesion in MCTD showing an interface dermatitis with prominent dyskeratosis and suprabasilar lymphocytosis similar to the changes seen in subacute cutaneous lupus erythematosus. There are also conspicuous vascular ectasia and areas of vascular dropout, a constellation of findings suggesting that the primary antigenic targets are both the epidermis and the microvasculature.