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Characteristics of patients with monoclonal gammopathy of undetermined significance (MGUS)

Characteristics of patients with monoclonal gammopathy of undetermined significance (MGUS)
Characteristic Screening study* Clinically diagnosed MGUS
Heavy chain type (percent)
IgG 69 70
IgM 17 15
IgA 11 12
Biclonal 3 3
Light chain type (percent)
Kappa 62 61
Lambda 38 39
Reduction in uninvolved immunoglobulins (percent) 28 38
Monoclonal urinary light chain detected (percent) 22 31
MGUS: monoclonal gammopathy of undetermined significance; Ig: immunoglobulin.
* Olmsted County prevalence study of 694 patients with MGUS diagnosed in a population-based screening study[1].
¶ Southeastern Minnesota study of 1384 patients with clinically diagnosed MGUS[2].
References:
  1. Kyle RA, Therneau TM, Rajkumar SV, et al. Prevalence of monoclonal gammopathy of undetermined significance. N Engl J Med 2006; 354:1362.
  2. Kyle RA, Therneau TM, Rajkumar SV, et al. A long-term study of prognosis in monoclonal gammopathy of undetermined significance. N Engl J Med 2002; 346:564.
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