Antibiotic therapy for Erysipelothrix rhusiopathiae infection

Antibiotic therapy for Erysipelothrix rhusiopathiae infection

Type of infection	Drug	Adult dose
Localized cutaneous infection
Preferred	Penicillin V	500 mg every 6 hours orally
Preferred	Amoxicillin	500 mg every 8 hours orally
Alternatives	Cephalexin	500 mg every 6 hours orally
	Ciprofloxacin*	250 mg every 12 hours orally
	Clindamycin	300 mg every 8 hours orally
	Erythromycin^¶	500 mg every 6 hours orally
Diffuse cutaneous infection OR systemic infection (bacteremia)
Preferred	Penicillin G	2 to 4 million units every 4 hours IV
Alternatives	Ceftriaxone	2 g every 24 hours IV
	Cefazolin	1 g every 8 hours IV
	Imipenem	500 mg every 6 hours IV
	Ciprofloxacin^Δ	400 mg every 12 hours IV
	Daptomycin	6 mg/kg every 24 hours IV

The duration of therapy for localized or diffuse cutaneous infection is 5 to 10 days. The duration of therapy for systemic infection (bacteremia) is at least 4 weeks; 14 days of intravenous therapy followed by 2 to 4 weeks of oral therapy has also been successful.

IV: intravenously.
* Other fluoroquinolones may be substituted.
¶ Other macrolides may be substituted.
Δ Other intravenous fluoroquinolones may be substituted.

Graphic 73058 Version 13.0

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Antibiotic therapy for Erysipelothrix rhusiopathiae infection