Summary of the neurologic manifestations of hypothyroidism

	Cardinal features	Relative frequency
Myxedema coma	Decreased mental status, bradycardia, hypothermia, hypotension, others	Rare
Cognitive impairment	Slowed mentation, poor concentration and short-term memory	Common in overt hypothyroidism; uncertain in subclinical hypothyroidism
Cerebellar ataxia	Gait most often affected, limb and speech involvement can occur	Uncertain; early studies suggest 10 to 30 percent
Carpal tunnel syndrome	Pain, numbness, weakness in median nerve distribution	Common 25 to 33 percent
Peripheral neuropathy	Predominantly sensory, often painful	Common, but rarely the presenting symptom
Myopathy	Ranges from asymptomatic serum CK elevation to cramps and myalgias to more disabling proximal muscle weakness	Common in at least one form

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