Effects of cytomegalovirus in transplant recipients

Direct effects

Infection of native tissues

Asymptomatic viral shedding (lungs, urine)

Acute "viral syndromes" – flu-like or mono-like illness (fever, myalgia)

Leukopenia, thrombocytopenia, fever

Pneumonia

Retinitis

Enteritis and/or colitis

Pancreatitis

Encephalitis

Adrenalitis and adrenal insufficiency

Infection of allograft

Hepatitis

Pneumonitis

Nephritis

Myocarditis

Pancreatitis

Indirect effects

Augmented risk for bacterial and fungal infections

Activation or accelerated infection due to other viruses (HCV, EBV, HHV6, HSV)

Allograft injury and rejection

Oncogenesis and proliferative syndromes:

EBV-associated PTLD

Accelerated atherogenesis (cardiac)

Bronchiolitis obliterans (lungs)

Toxicities of therapy

Cost of prophylaxis and therapy

HCV: hepatitis C virus; EBV: Epstein-Barr virus; HHV: human herpesvirus; HSV: herpes simplex virus; PTLD: posttransplant lymphoproliferative disorder.

Graphic 72973 Version 5.0

خرید پکیج

Effects of cytomegalovirus in transplant recipients