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Aphasia syndromes

Aphasia syndromes
Syndrome Flu Rep Comp Read Write Localization
Broca + + "Broca" area: left inferior frontal, often anterior MCA branch occlusion
Wernicke + "Wernicke" area: left superior temporal and inferior parietal region, often posterior MCA branch occlusion
Anomic + + + ± ± Temporal, parietal, and occipital regions of cortex outside of classical language areas
Conduction + + + ± Superior temporal gyrus, inferior parietal region adjacent to temporal lobe; classically in arcuate fasciculus
Transcortical motor + + + Left mesial frontal, especially supplementary motor area; anterior cerebral artery occlusion
Transcortical sensory + + Left posterior watershed zone between MCA and PCA territories
Transcortical mixed + Anterior and posterior watershed zones, effectively disconnecting perisylvian cortex from other cortical regions
Global Large MCA or left carotid inclusions infarcting a vast region of the left hemisphere
Pure word deafness + + + + Left or bilateral superior temporal gyrus lesions
Pure alexia + + + + Left occipital lobe with involvement of splenium of corpus callosum
Aphemia + + + + Motor cortex outflow to articulators
Pure agraphia + + + + Left inferior frontal region
–: impaired; +: relatively spared; ±: may be impaired; Comp: comprehension; Flu: fluency; MCA: middle cerebral artery; PCA: posterior cerebral artery; Read: reading; Rep: repetition; Write: writing.
Data from: Mendez MF, Clark DG. Neuropsychiatric aspects of aphasia and related disorders. In: The American Psychiatric Publishing Textbook of Neuropsychiatry and Behavioral Neurosciences, 5th ed, Yudofsky SC, Hales RH (Eds), American Psychiatric Publishing, Washington, DC 2007. p.522.
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